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First PINK1 phosphorylates the ubiquitin protein (Ub), and the phosphorylated ubiquitin (pUb) subsequently binds to RING1, leading to the release of UBL, which is immediately followed by phosphorylation of UBL by PINK1, and binding of the phosphorylated UBL to RING0, and the subsequent release of RING2 [33, 34]

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