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Over the following average follow-up period of 11 months, incidence rates per 1,000 person-years were 21.4 for osteoarthritis, 21.1 for CKD, 20.3 for OSA, and 3.9 for heart failure

The main reason is that GLP-1 is a peptide

Direct action on the area postrema in the brainstem triggers the sensation, while delayed gastric emptying creates a physical sensation of fullness that contributes to discomfort

JAMA (2019) 321:1466

they reduce appetite

The plaintiffs attorneys have filed several confidential court documents to oppose Eli Lillys request to dismiss the lawsuits and disqualify the plaintiffs experts