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1 Lumbar/intervertebral disc degeneration (IDD) is one of the most common diagnoses involved in LBP and results in lumbar instability and height loss, which in turn leads to symptomatic nerve compression, intervertebral foramen stenosis, adjacent segment degeneration, and instability-induced LBP

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Endogenous blood melatonin concentrations are higher in newborns with late-onset sepsis 106 , and its use as an adjuvant therapy in the treatment of sepsis is associated with improvement of clinical and laboratory outcomes 107