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Inhibition of SGLT-1 in the small intestine causes more glucose transport to the distal intestine and colon, resulting in greater fermentation of glucose to SCFAs by luminal bacteria and increased sustained release of GLP-1 in the distal intestine [174] (Fig

10.1097/WNN.0000000000000285 19 BlaaA

The evidence reviewed herein does not yet support formal treatment guidelines, given the predominance of low-level data and the absence of head-to-head trials in MC4R -deficient populations

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The right framing is exploratory, in patients without contraindications, and only inside a physician-led plan

2024 Oct 15;44(11):NP809-NP818 Functional and Aesthetic Periorbital, Ocular Adnexal and Ocular Surface Changes Linked to GLP-1 Receptor Agonists