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Clinical trials demonstrate mean weight reductions of 2022% over 72 weeks in participants with obesity, alongside improvements in fasting glucose and HbA1c

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We and others previously demonstrated GDF8 and ActA are the two major ligands which mediate the muscle minimization actions of the ActRIIA/B receptors in non-obese mice and NHPs 22,28,30 , and we have further shown that dual blockade of GDF8 and ActA led to much larger increases in muscle mass than blocking either ligand individually, and that dual blockade matched the muscle growth actions of broader ActRIIA/B blockade 28 , similar to effects seen when using a dominant-negative type II receptor or pro-domains of GDF8 and activins 22,26,27

After evaluating your consultation, a provider licensed in your state will prescribe a weight management treatment plan (if clinically appropriate)

E., & Strasser-Weippl, K