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However, in the high GLP-1 group, the change from baseline in the early (30-minute) LS-mean insulin response to OGTT was increased significantly at 12 weeks of treatment compared to the low GLP-1 groups [between group difference 31.13 U/ml (95% CI 9.94, 52.33 U/ml)

286,287,288,289,290,291,292 Overall, GLP-1 reduced the risk of MACE by 14% according to a meta-analysis comprising these trials

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Preclinical studies have explored downstream effects on antioxidant signalling, extracellular matrix remodelling, and gene-expression responses in cultured cells