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DPP-4i CVOTs With respect to the primary endpoint (3P-MACE), the CV safety profile of saxagliptin, sitagliptin and linagliptin was established in the respective CVOTs [64,65,66]
Tiriveedhi V, Banan B, Deepti S, et al
Structural Stability There's another benefit: some peptides undergo deamidation at neutral or basic pH asparagine residues slowly convert to aspartate, which degrades the peptide's activity over time
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This puts aged and fermented foods at a substantial risk of triggering histamine problems
doi: 10.1038/cdd.2010.79 60 BoldyrevAABryushkovaEAVladychenskayaEA
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