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Treatment with Fc-GLP-1 in mice fed a chow diet significantly increased Acta2 (encoding -SMA), Col1a1 , Tgfb and Mmp2 mRNAs (Fig

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Sin embargo, con el tiempo, la CBP pierde la capacidad de generar hiperinsulinemia compensatoria y se produce dficit de insulina, lo que conlleva a la prdida de la regulacin de la glucosa y a la hiperglucemia sostenida, que genera glucotoxicidad y lipotoxicidad, conllevando a la disfuncin y muerte de la CBP, lo cual denota un importante ciclo vicioso 41