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In the diabetes-specific TRANSCEND-T2D-1 trial, weight loss was 16.8% substantial but lower than non-diabetic obesity trials, consistent with patterns across the GLP-1 drug class

Recommended Retatrutide Dosing Schedule and Titration Guidance In Phase 2 trials, retatrutide was titrated from a starting dose of 0.5 mg once weekly, with incremental increases at approximately four-weekly intervals to maintenance doses of 4 mg, 8 mg, or 12 mg

The co-primary endpoints were body weight change and WOMAC pain subscale change at 68 weeks

Could GLP-1 Receptor Agonists Be Useful in ME/CFS

A meaningful reduction in caloric intake, reduced snacking, and improved satiety after meals are all positive indicators

Typically the few days following my injection, Im not overly hungry, so I lean on higher nutrient-dense foods