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The delivery system not only improves the water solubility and bioavailability of sorafenib, but also increases the accumulation of the drug in the tumor site through an active targeting mechanism, thereby maintaining efficacy at lower doses and reducing toxic reactions (Table 2)

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10.1016/j.freeradbiomed.2013.02.011 [DOI] [PubMed] [Google Scholar] Liu B., Mosienko V., Vaccari Cardoso B., Prokudina D., Huentelman M., Teschemacher A

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Patients who have completed a cycle of one and want to address the remaining symptom cluster with the other