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In response to viral infections, type I IFNs are produced by innate immune cells, including dendritic cells (DCs), to activate T and B cells that produce cytokines and autoantibodies to stimulate DCs to present more autoantigens in systemic autoimmune diseases (10)

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and analyzing paramagnetic rim lesions for evidence of chronic inflammation lacks proper standardization and may be unreliable due to a lack of validated multi-center studies

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