This decision should be based on response, side effects, hunger, weight trend, labs, and patient goals
The shift in gut motility, combined with changes in bile acid absorption and fluid balance in the intestines, can lead to diarrhea, particularly during dose increases
A report from Impact Analytics estimates that these changing size curves could cost retailers up to $20 million annually due to misaligned inventory and excess production of larger sizes
Because of strong evidence for such side-effects, they are described in patient leaflets as very common although manufacturers note they usually go away over time
Losing 30 pounds on semaglutide could mean losing 12 pounds of muscle
J Cutan Pathol 41(1):6365