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When antidepressant effects persisted after administering the therapy to global GLP-1 receptor knockout mice, their suspicions were confirmed

**Apply Generously and Reapply Often:** Apply at least a shot glass full (approximately 2 milligrams per square centimeter of skin) to all exposed skin 15-30 minutes before going outside

It blocks those receptors non-competitively, triggers a downstream cascade of AMPA activation and BDNF release, and produces the neuroplastic window that makes it effective for treatment-resistant depression, anxiety, and PTSD

This clearly shows that SAM supplementation negatively disrupts systemic methyl metabolism