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Acknowledgements We thank the Bloomington stock center, TsingHua Fly Center, Jin Jiang, Andreas Bergmann, Lei Xue, Wenzhe Li for fly stocks

Needle: Common lab supply choice is a 29-31 gauge insulin syringe with a short needle

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Cagrilintide Overview Cagrilintide stands as the first long-acting amylin analogue specifically engineered for once-weekly administration, addressing the limitations of earlier amylin-based therapeutics like pramlintide

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