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The phase 2b SOLSTICE randomized placebo-controlled clinical trial involved 406 adults with type 2 diabetes

Its a minimal risk, but its not zero, says Muskin

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Decreased appetite is an expected pharmacological effect rather than an adverse event, though the degree of appetite suppression can be more pronounced than some patients anticipate

A randomized, double-blind, placebo-controlled in 129 young healthy adults found that taking a supplement that contained ten times the daily intake recommendations for nine different vitamins (vitamin A, thiamin, riboflavin, niacin, vitamin B 6 , folic acid, vitamin B 12 , vitamin C, vitamin E) for one year improved one self-assessment of mood, i.e., being more agreeable (137)