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Therefore, the glycocalyx may serve as a therapeutic target to restore BBB function

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Cerebellar Stimulation for Parkinsonism and Dystonia As mentioned above, cerebellar dysfunction is additionally implicated in some aspects of PD, specifically tremor, and dystonia [47, 49,50,51,52, 161,162,163], but little is known about the potential use of cerebellar surgery for treatment of Parkinsonism and dystonia

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These epigenetic mechanisms include differential DNA methylation, histone modifications, and miRNA expression that affect genes modulating energy metabolism, appetite control, and insulin signaling [121, 130, 131]