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In contrast, it has been observed that older people have a lower risk for the rejection of heart transplants [139] which indicates that an increased immunosuppressive state improves their transplantation tolerance

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This heterogeneity complicates the elucidation of pharmacokinetic and pharmacodynamic profiles, particularly in compounded preparations, thereby hindering standardization and clinical validation

Hafiane A, Favari E, Daskalopoulou SS, Vuilleumier N, Frias MA