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Glutathione and Immune Modulation Depleted intracellular glutathione has been associated with shifts in T-helper cell balance, specifically a Th1/Th2 imbalance, and increased pro-inflammatory cytokine signalling, including elevated tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)

So, to reiterate: Vitamin B12 deficiency: MMA elevated, homocysteine elevated Folate deficiency: MMA normal, homocysteine elevated In the study posted earlier, migraine patients had markedly higher MMA levels, confirming a true B12 deficiency state

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