As for the secondary outcome measures of gastrocnemius muscle mass and flexion foot contracture, there was a significant decrease in muscle mass seen in the right hind limb that underwent sciatic nerve transection, in comparison to the left hind limb that was not operated on
Figure 7: Recovery of motor functioning in groups of mice administered MSC, G-CSK, and Dihexa, determined by walking track foot prints of normal and sciatic nerve resected limbs
For intracerebroventricular administration, both low doses of 0.1 nmol and high doses of 1.0 nmol of Dihexa significantly reduced escape latency compared to the scopolamine group from day 2 onwards
Following the end of the sensation and motor studies, the rats were euthanized and both the left and right gastrocnemius muscles were dissected and weighed in order to compare the muscle mass of the operated limb (right) versus the non-operated limb (left) [2]
These properties position Dihexa as a key molecule in advancing the study of neuroplasticity , memory formation , and cognitive repair
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