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Cyanocobalamin is contraindicated in individuals with Leber's hereditary optic neuropathy

Clear explanation of risks : Any doctor proposing an off-label procedure has an ethical obligation to discuss all known risks, including those described in the section above

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The following chemical reactions are catalyzed by XO (Figure 16): Inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions