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For example, after GLP-1 binding the transmembrane helices 1 (TM1) rotates clockwise when looking down the membrane helices from the extracellular face (see TM1 marked in Figure 6) and a kink is introduced in the transmembrane helix 6 (TM6), as is typical for all class B1 GPCRs
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Olfactory dysfunction, including parosmia, has been associated with liraglutide use 46 , likely reflecting GLP-1R-mediated modulation of odor-evoked insulin secretion and foraging behaviors in the olfactory bulb 51,52
Membrane fluidity and its roles in the perception of environmental signals
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