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For some, its the weight loss

Use of dipeptidyl peptidase-4 inhibitors and risk of bone fracture in patients with type 2 diabetes in Germanya retrospective analysis of real-world data

Heart Failure Populations Show Consistent Benefits For patients with both obesity and heart failure, semaglutide's cardiovascular protection appears particularly robust

(2016) The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials, Obesity Reviews, 17(10), pp

This suggests that NAD+ repletion can have metabolic benefits in humans, though the magnitude depends on baseline NAD+ status and the specific precursor used

If making diet, exercise, and dose changes for 8+ weeks still results in a plateau, ask your doctor about adding short-term prescription plateau breakers like phentermine to get lost again