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10.1056/NEJMcp1113996 40 StablerS

Simple timing framework Baseline Discuss baseline labs before starting, especially with autoimmune disease, infection risk, cancer history, liver or kidney issues, anticoagulant use, or a recent major injury

Clinicians should counsel patients accordingly: early weight loss on retatrutide will lag behind that of faster-escalating agents, but the trajectory continues rising for months after Saxenda patients have plateaued

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Through the inhibition of gastric emptying and reduction of food intake, GLP-1 receptor agonists can significantly suppress nutrient absorption, potentially leading to a decrease in muscle mass [54, 60]

Healthcare professionals observe for any adverse reactions or complications, although they are rare