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For psoriasis specifically, topical application has obvious appeal since the condition manifests on the skin surface

doi: 10.1186/s12916-018-1116-5

It's important to note that weight loss itself is an evidence-based therapy for GERD, so the weight reduction achieved with these medications may actually improve reflux symptoms in some patients, potentially offsetting any direct effects on the gastroesophageal junction

With strong CYP2B6 inhibitors: Max 1 tablet twice daily (Medscape, 2025)