reported reduction of body weight, HbA1c levels and blood pressure after 6-month treatment with sitagliptin [135]
Pica behavior is a validated endpoint to assess the ability of a compound to induce nausea/malaise in non-vomiting species, as mouse, based on the monitoring of non-nutritive (kaolin) food intake, as an index of gastrointestinal discomfort 43,44
But for many people, the base prices are too high a barrier to consider scaling
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13 While the volume of patients is expected to skyrocket, the reduction in per-patient revenue will force originators to rely even more heavily on their long-term IP strategies and manufacturing scale to sustain the growth rates expected by Wall Street
Restraints High Treatment Costs and Limited Affordability A major obstacle is affordability, as GLP-1 analogue therapies are substantially more costly than traditional diabetes treatments