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dose adjustments needed Comparison: Retatrutide vs Wegovy vs Mounjaro Side Effects Side-by-Side Comparison Key Differences Retatrutide unique: Dysesthesia (20.9%) NOT seen with others Highest efficacy (28.328.7% weight loss) Higher discontinuation in osteoarthritis population (18.2%), more comparable in general obesity (11.3%) Semaglutide unique: Best tolerability (6.9% discontinuation) More constipation (24%) Lower efficacy (14.9% weight loss) Tirzepatide middle ground: Moderate tolerability (6.2% discontinuation) Strong efficacy (22.5% weight loss) Similar GI profile to both Bottom line: All three have similar GI side effects

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