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A 2018 paper Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics out of Johns Hopkins University Center for Nanomedicine described an improved dendrimer-NAC conjugate called TPP-D-NAC which was able to target the dysfunctional mitochondria found in activated microglial cells and reduce oxidative stress levels substantially as well
This article provides evidence-based guidance aligned with UK clinical practice and MHRA-approved prescribing information
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