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At 5 mg/ml concentration, doses above 5 mg require more than 1 ml of liquid

Ellis CA, Petrovski S, Berkovic SF

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When IGF1 binding to IGF-IR/InsR is blocked by the anti-IGF-IR mAb cixutumumab, IGF1 binding to integrin v3 increases, resulting in activation of v3 and its downstream effectors Src, FAK, and PI3K, which confers cixutumumab resistance [172]