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10.1007/BF00711381

Shah put it pretty simply

Peer-reviewed clinical trial data published in the New England Journal of Medicine establishing semaglutides efficacy for chronic weight management, with average weight loss of 14.9 percent of body weight at 68 weeks positions these as a fundamentally different category of intervention than peptides like GHK-Cu

However, as with any active ingredient, a patch test is advised before first use

Together, these steps outline a feasible bench-to-bedside strategy, addressing both regulatory and translational gaps

No serious adverse events have been reported in the available literature at therapeutic doses