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Secondary aims Secondary aims are to determine if, compared to placebo, treatment with 400 mg oral SAMe for 180 days will 1) maintain or improve performance as measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), 2) result in epigenetic changes in DNA methylation, and 3) be safe

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Nevertheless, the pooled analysis of 16 trials suggested improvements in the summary measure of patients' global functioning (assessed with the Clinical Global Impressions [CGI-I] scale) after 12 and 24 weeks of (but not after 52 weeks) of ALCAR treatment (1-3 g/day) and in cognitive performance (assessed with the Mini-Mental State Examination [MMSE] scale) after 24 weeks (but not at 12 or 52 weeks) (104)

A review of the use of biotin for hair loss