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One of MOTS-C's downstream effects is increasing intracellular NAD+ utilization the mitochondria are running harder, so they're consuming more of the NAD+ pool
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CAS 137525-51-0)
This progressive deficit leads to insufficient sirtuin activation, mitochondrial respiratory chain dysfunction, and decreased ATP production (Rajman et al., Cell Metab 2018)
When the herniated material compresses a nerve root, patients typically experience radiating pain (sciatica), numbness, tingling, or muscle weakness in the leg or foot served by that nerve
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