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Amyloidogenicity and aggregate cytotoxicity of human Glucagon-Like Peptide-1 (hGLP-1), 2009

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Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, and pregnancy

The closing of the extracellular regions by the ECD and the reorganization of the TMD conformation interfere with the binding of GLP-1 to the orthosteric pocket in the inactive state of full-length GLP-1R (Supplementary Fig

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