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The sequence identity between mTYR and hTYR is only 25%, implying limited structural similarity and transferability of research results from mTYR to hTYR

Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating -oxidation-dependent mitochondrial ROS production

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Curr Opin Immunol 22(2):231237 Biswas SK et al (2006) A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)

Beyond these methodological and biological challenges, several core evidence gaps deserve emphasis

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