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Daily use of broad-spectrum SPF is essential, as melanin synthesis can outpace lightening agents without sunscreen

As a result, -HB regulates the activity of ERK1/2 through the HCAR2/Ca+/cAMP/PKA/Raf1 pathway, ultimately enhancing PPAR function through post-translational changes and decreasing IR linked to T2DM

Key biomarkers include glutathione levels, malondialdehyde (MDA), 8-isoprostane, and C-reactive protein to establish baseline oxidative burden

10.1038/ncomms14694 17 HongJ.XuB.HuX.LiuC.LiuH.TianJ.et al (2025)

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These agents reduce HbA1c levels, facilitate weight loss, and exhibit cardiovascular protective effects, making them an integral component of T2DM and obesity management