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We first emulated two cardiovascular outcome trials, SUSTAIN-6 (semaglutide versus sitagliptin as placebo proxy) and SURPASS-CVOT (tirzepatide versus dulaglutide), to benchmark and self-critically evaluate our design, data, and analytic framework

Incorporating fermented foods like Greek yogurt, kefir, kimchi, and sauerkraut can help replenish beneficial gut bacteria and alleviate bloating

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The genotyping primers are listed in Table 1

The aforementioned glycolytic reprogramming drives profound lactate and proton accumulation

It works by mimicking the activity of a glucagon-like peptide-1 (GLP-1) receptor agonist, which enhances insulin secretion and supports stable blood glucose