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Interest in this possibility was rekindled by John Dupr, a Canadian endocrinologist at St Thomas' Hospital in London

Meanwhile, emerging evidence highlights BBRs novel molecular targets for anti-obesity: (1) AMPK/PGC-1 axis activation and SIRT1-mediated deacetylation

Long-chain acylcarnitines are essential intermediates in the carnitine shuttle, and their pathological buildup is associated with mitochondrial dysfunction, oxidative stress, and inflammationkey processes in DKD progression [33, 39, 49,50,51,52]

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Together, these pathways make retatrutide one of the most promising future therapies for cardiometabolic health