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Importantly, arginine deprivation therapy has been shown to alleviate fibrosis in vivo and enhance the antifibrotic efficacy of nintedanib [88]

Blood samples were taken at the following times in relation to dosing: Predose (day 0) for all 4 groups then 5 min, 6 h, 1, 3, 5, 6, 7, 8, 9, 10, 12 and 30 days for the 1 mg/kg (i.v.) group

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doi: 10.1177/0115426592007004175 379

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