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If ultimately adopted by the FDA, this could allow qualifying compounding pharmacies to legally compound these substances under federal compounding regulations

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These reactions are more likely when treatment is started too rapidly, when the dose is excessive or when methylation status has not been evaluated functionally

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The 2.5 mg starting dose is explicitly a tolerability dose in trials it was not intended to drive weight loss on its own, but to let the gut acclimate before therapeutic doses begin