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Front Pharmacol (2021) 12:788558

Off-Label and Adjacent Options Metformin , a common and inexpensive type 2 diabetes drug, is sometimes used off-label where weight is tied to insulin resistance, including in polycystic ovary syndrome (PCOS)

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It is estimated that about 415 million people had diabetes in 2015, and this number may continue to rise to 642 million by 2040