Readers researching the broader hepatocyte growth factor / c-Met pathway for cognitive indications should be aware that Fosgonimeton (development code ATH-1017), a structurally distinct small-molecule prodrug developed by Athira Pharma as an HGF positive modulator, has been investigated in three clinical trials in dementia indications
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Cancer Discov 5:8295 Mender I, Gryaznov S, Shay JW (2015b) A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells
These ideas rely on data drawn from other studies
doi: 10.1515/CCLM.2009.350
History of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 represents absolute contraindications