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doi:10.1007/s00011-007-7056-8

Some studies have reported no significant differences in IGF-1 levels or side effects following interventions such as lycopene supplementation or calorie restriction, suggesting a lack of direct effect in certain cases

This finding supports the notion that DEM exposure alone increases oxidative stress in F

Disease-specific proteins (A, -syn, mHTT) induce mitochondrial calcium overload and oxidative stress, which sensitize the mPTP, leading to mitochondrial failure, mtDNA release, and neuronal degeneration