Whilst PT-141 is a variant of Melanotan, Melanotan 2 is primarily researched for tanning it may have indirect effects on libido due to its melanogenesis-stimulating properties, whereas PT-141 directly targets sexual function by activating melanocortin receptors in the brain
It inhibits NNMT, an enzyme that methylates nicotinamide (a precursor to NAD+)
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doi: 10.1007/s12263-011-0218-x 254 WuYWangYHuAShuXHuangWLiuJet al
Efficacy and safety of Tregopil, a novel, ultra-rapid acting oral prandial insulin analog, as part of a basal-bolus regimen in type 2 diabetes: a randomized, active-controlled Phase 2/3 study