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Vpr induces oxidative stress by stabilizing p53 protein, increasing transforming growth factor-beta protein levels and ROS production, and suppressing antioxidant enzymes 118,119,120

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The transgene carrying this 3UTR replacement was otherwise identical to the sygl-1 transgene described above ( Fig 1C ), including insertion into the same chromosomal site and rescue of lst-1 sygl-1 double mutants from sterility to fertility ( S3A Fig )

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