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"We now have more than two years of experience using these medicines for weight loss, and what we're seeing is that, in some cases, one drug is better, it has fewer side effects, and perhaps greater efficacy than the other," Aronne said

Tirzepatide as Compared with Semaglutide for the Treatment of Obesity

GLP-1 (7-36) is a natural peptide hormone that is secreted in response to food, activates the GLP-1 receptor (GLP-1R) and is a key regulator in glycaemic control

Hence, most patients opt for a once-weekly subcutaneous injection

Mainstay treatments are renin-angiotensin-aldosterone system inhibitors, mineralocorticosteroid antagonists and -blockers, and, as mentioned earlier, SGLT-2 inhibitors, especially in people with comorbid diabetes