Mantener el azcar en sangre dentro de un rango normal ayuda a proteger la salud metablica y cardiovascular a largo plazo
Mounjaro Mechanism of Action: The Full GIP + GLP-1 Dual-Agonist Pathway At a glance Drug class / GIP + GLP-1 dual receptor agonist (twincretin) Molecular weight / approximately 4,813 Da fatty-acid conjugated peptide Primary receptor targets / GIPR and GLP-1R (distinct G-protein coupled receptors) FDA approval date / May 13, 2022 (type 2 diabetes)
Regulation of the hypothalamic-pituitary-adrenocortical stress response
Injectable GLP-1s must be refrigerated
staggered titration Cycle driver GI tolerance sets the pace Retatrutide Loading 2 mg 4 mg 8 mg (weeks 1-12) Frequency Once weekly Maintenance 12 mg weekly Route SubQ Cagrilintide Loading Start Week 9: 0.25 0.5 1.0 1.7 mg Frequency Once weekly Maintenance 2.4 mg weekly Route SubQ Weekly Schedule Example (Maintenance Phase) Monday Retatrutide 12 mg (one site) + Cagrilintide 2.4 mg (different site) Tuesday No injections Wednesday No injections Thursday No injections Friday No injections Saturday No injections Sunday No injections Both compounds are once-weekly
Oh GS, Kim HJ, Shen A, Lee SB, Khadka D, Pandit A, et al
