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Lastly, B12 is vital for red blood cell production and DNA synthesis

Beyond the biological effects, stress often leads to behaviors that undermine weight loss: skipping workouts, making quick and less healthy food choices, drinking more alcohol, and sleeping poorly

All statistical analyses were conducted using GraphPad Prism for Windows 8.0 (Graphpad Software Inc., CA, USA), SPSS Statistics 26.0 (SPSS Inc., Ill., USA), and Image J (version 1.53 K, National Institutes of Health, USA)

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I built this matrix by mapping each row to the single trial endpoint that produced the highest-quality primary evidence as of mid-2026: percent body-weight change for efficacy (Jastreboff 2023, SURMOUNT-1, STEP 1), three-point MACE for cardiovascular (SELECT), MRI-PDFF for hepatic fat (retatrutide Phase 2 sub-analyses, [unverified primary source]), and treatment-emergent adverse event rates for GI burden