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The number of subjects with MRE values increasing 15%, indicating increased fibrosis, was lower for sema vs PBO at week 48 (1 vs 8, respectively)

What this means for you in practice You dont need to find a vein

It is important to distinguish between a direct drug effect and the underlying condition

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Guirguis says any new therapy needs to be cost effective, safe, efficacious, have good bioavailability, have a simple dosing regimen and get patients acceptability and affordability

These substances can also exist in their respective phosphorylated forms and can be converted, primarily in the liver, to PLP, an active cofactor essential for a number of enzyme-catalyzed reactions