A major open question at this point is how the spending impact of these drugs might compare to the avoided cost of alternative treatments
Prescription drug prices in the U.S
Mounjaro delivers superior A1C reductions: up to 2.3-2.4% versus 1.4-1.8% for Rybelsus
Obesity 30(4):841857 Coulter AA, Rebello CJ, Greenway FL (2018) Centrally acting drugs for obesity: past, present, and future
Side effect rates at 12mg are meaningfully higher than at 8mg: Nausea: 43.2% of participants (vs 38.1% at 9mg) Diarrhea: 33.1% (vs 34.7% at 9mg) Constipation: 25.0% (vs 21.8% at 9mg) Vomiting: 20.9% (vs 20.4% at 9mg) The decision between 8mg, 10mg, and 12mg as a maintenance dose should be made based on individual response
In practice, this is where patients often need more guidance than they realize