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Furthermore, increased LDL cholesterol and baseline plasma cholesterol have been linked to an increased risk of colorectal neoplasms (Tian et al., 2015) and high-grade prostate cancer (Shafique et al., 2012), respectively, and increased intracellular cholesterol was indeed found in patient-collected prostate cancer cells compared to non-cancerous prostate cells (Singh et al., 2017)

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No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

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Clinical Data: Weight Reduction, accessed November 24, 2025

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes