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Moreover, insulin resistance of the adipose tissue, associated with overweight/obesity, contributes to the flux of FFA from adipose tissue to the liver through unrestricted lipolysis ( de novo lipogenesis, i.e., hepatic FFA synthesis, seems to contribute to lipid deposition ( Figure 2 The gut-derived incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) are responsible for the so-called incretin effect (i.e., the potentiation of glucose-stimulated insulin secretion after meal ingestion) ( Glucagon is a key hormone in the regulation of overall energy homeostasis during the fasting state and other energy-demanding situations
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By eliminating the need for injections, oral semaglutide may improve adherence and support earlier initiation of therapy broadening access to cardiovascular protection for patients who might otherwise delay or avoid treatment due to reluctance toward injectables
Semaglutide can interact with medications that affect blood sugar, such as insulin
